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Advancing CAR-T Therapies: The Importance of Closed Processes in Manufacturing and Future Innovations

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New technologies and techniques for manufacturing CAR-T cells are expanding its application from cancer to autoimmune diseases and rare diseases. Research is quickly evolving, supported by scalable solutions, innovative products designed for Current Good Manufacturing Practice (CGMP) in cell therapy, and the use of closed and automatable instrumentation.

Chapters include:

  • A Closed, Autologous Bioprocess Optimized for TCR‐T Cell Therapies
  • TREM1/DAP12 Based Novel Multiple Chain CAR‐T Cells Targeting DLL3 Show Robust Anti‐tumor Efficacy for Small Cell Lung Cancer
  • Efficient CAR-T cell Manufacturing Using a Closed and Integrated Instrument Workflow
  • Streamlining Cell Therapy Manufacturing with Rapid and Reliable Bead Removal
  • An Automated 24‐hour CAR‐T Manufacturing Process

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